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where to buy lasix online The signaling sequence induced by E2 at the membrane site is as follows 1 E2 binding to mER, 2 E2 mER complexes with p85 to activate PI3K, 3 activating calcium independent PKC, 4 phosphorylating the L type calcium channel, 5 inducing calcium influx, 6 activating calcium dependent PKCs, 7 activating Src kinase, 8 activating the MEK ERK1 2 pathway, 9 ERK translocates to the nucleus, 10 activating and phosphorylating CREB, 11 enhancing transcription of antiapoptotic genes Bcl 2 and Bcl xl, which enhance mitochondrial vitality, and spinophilin, which encourages synaptic growth, 12 simultaneously, estrogen activation of PI3K leads to activation of Akt, which phosphorylates and inhibits the proapoptotic protein BAD |
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